We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac threat elements using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this patient additionally had polycythemia, doubtless secondary to high-dose testosterone. The affected person underwent profitable percutaneous intervention of the proper coronary artery. Physicians and sufferers should concentrate on the medical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a element of endothelial dysfunction has been proposed, which may contribute to irregular vessel reactivity. However, testosterone in physiologic doses may even be useful in patients with angina , have larger ischemic thresholds and improved high quality of life .
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Relationship between endogenous sex hormone levels, lipoproteins and coronary atherosclerosis in males undergoing coronary angiography. Basaria S, Dobs AS. Risks versus advantages of testosterone remedy in elderly men. Scientific and technological companies and analysis and design relating thereto; industrial evaluation and analysis companies; design and improvement of pc hardware and software.
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Anabolic Steroids, Acute Myocardial Infarction And Polycythemia: A Case Report And Review Of The Literature
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Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery illness . Therefore, an interaction of endogenous elements of the patient’s threat profile as well as the testosterone dosing could additionally be issues of whether or not opposed events happen. Erythrocytosis has been reported as a potential impact of testosterone, which could be beneficial in sufferers with anemia. The biggest threat of erythrocytosis happens with injectable forms of testosterone in contrast with transdermal preparations, particularly in supraphysiologic doses. An enhance of as much as 44% of the baseline hematocrit has been reported . Moreover, testosterone has been used within the therapy of decreased muscle mass and bone density as nicely as anemia. The position testosterone might play within the improvement of cardiovascular disease has increasingly turn into the subject of current curiosity .
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